Recruiting Older Participants: A Complex Challenge

As a leader in Alzheimer’s clinical research, K2 Medical Research is committed to exceptional participant care while addressing the growing challenges of recruitment. The K2 team needed to scale and accelerate recruitment without compromising their participant-centric approach.

Key challenges included:

• Older Demographics: Participants aged 55+ require extra time and support for prescreening, scheduling, and logistics coordination.

• Multilingual Engagement: Operating in a diverse region, K2 needed seamless bilingual communication for English- and Spanish-speaking participants.

• Logistical Complexities: Trials with a population age 50+ require additional support, such as transportation arrangements and visit companions, placing strain on staff.

To address these challenges, K2 sought a scalable technology solution to enhance efficiency while maintaining participant-first care.

K2 Leverages Grove to Streamline 24/7 Personalized Recruitment

K2 partnered with Grove AI to deploy Grace, the world’s most advanced AI clinical research agent, and the Grove AI PRM™ platform, creating a participant-centric solution to streamline recruitment.

With Grove AI’s technology, K2 achieved:

• 24/7 Personalized Engagement: Grace autonomously guided participants through prescreening, scheduling, and follow-ups, addressing the unique needs of the 55+ demographic.

• Participant-Centric Adaptability: Grace used phone calls, texts, and emails to engage participants, schedule callbacks, reschedule appointments, and connect participants with site staff.

• Bilingual Support: Grace delivered bilingual communication, ensuring inclusivity for English- and Spanish-speaking participants.

• Streamlined Logistics: Grace automated reminders, transportation coordination, and live support, reducing logistical burdens on staff and participants.

• Quality Assurance and Compliance: Grace operated under IRB-approved protocols, had end-to-end encryption, and was fully HIPAA-compliant.

This approach enabled K2 to scale recruitment efficiently while maintaining a high standard of participant care

K2 Achieves Faster, More Diverse Recruitment

In less than a month, K2 achieved significant recruitment improvements:

• Increased Engagement: Grace contacted 1,466 participants, resulting in 14,956 personalized interactions via calls, texts, and emails.

• Prescreening Success: Grace prescreened and scheduled 175 participants (12%) for in-clinic visits.

• Diversity Expansion: Grace conducted 10.3% of interactions in Spanish, ensuring inclusivity for non-English speakers.

• Increased Conversions: Of the participants scheduled for in-person visits, 41% attended prescreening visits, and 66% advanced to screening for vaccine and Alzheimer’s trials.

Using data and AI-driven insights from the PRM, the K2 team refined recruitment strategies, improved participant experiences, and achieved higher conversion rates.

K2 Continues to Accelerate Clinical Operations with Grove

Today, K2 continues accelerating participant recruitment and engagement using Grove, managing tens of thousands of participant interactions efficiently and effectively across use cases from prescreening to follow-ups. The impact was recognized through an abstract publication at the leading 2024 Clinical Trials on Alzheimer's Disease (CTAD) Conference. By leveraging Grove, K2 has set a new standard for scalable, participant-first clinical trial recruitment in participant populations aged 50+.